I’ve never had a VST not work on Linux through WINE and a bridge. Native Instruments plugins are a bit of a pain due to Native Access, but it’s still possible to get running. Serum works, but requires a DLL bypass. Most Windows-only DAWs also work via WINE, but I’d recommend checking out Bitwig.

Also check out darktable instead of Lightroom. I haven’t used either, but I hear darktable is a good replacement.

Not sure about Maschine hardware since I don’t own any.