My cat once brought in a North American shrew in the house and I thought “what a weird looking mouse!” So, I went to scoop it up in a dust pan and drop it out side and the little shit bit my finger! Anyways, got it outside and went to look it up and found out they (the NA shrew) were venomous! Luckily the bite was superficial and I only had slight redness for the night.

Fun fact about the shrew is apparently it is highly territorial and can defend a territory of > 1 square mile, and somehow my cat found the one shrew in a sq mile area in our backyard which is like a 1/16 acre neighborhood plot lol

Well, as a pharmacist whose been stable on 50mg of vyvanse for more than 3 years, your wife and Doc are both incorrect…

Both are stimulants, yes, but

Vyvanse is an amphetamine and works to produce more neurotransmitters you don’t already have.

Cocaine is a reuptake inhibitor… thus preventing the breakdown of neurotransmitters you do already have.

While fundamentally they may look like they’re doing the same thing, they are in fact 2 totally different mechanisms. Furthermore, in neurotransmitter depletion the effects of cocaine will severely diminish, where as amphetamines will thrive.

Def not a math major (BS/PharmD), but your explanation was like seeing through a visual illusion for the first time! lol

I was always taught PEMDAS growing up, and that the MD and the AS was read left to right in an equation like above. But stating the division as a fraction completely changes my mind now about how this calculation works. I think what would happen in a calculation I use every day if the former was used.

Example: Cockcroft-Gault Equation (estimation of renal function)

(140-age)(kg) / 72(SCr) vs (140-age) X kg ➗72 X SCr

In the first eq (correct one) an 80yo patient who weighs 65kg and has an SCr ~ 1.5 = 36.11

In the latter it = 81.25 (waaay too high for an 80yo lol)

edit: calculation variable

Maybe it’s early in the morning and I am not quite awake, but I have no idea what you are talking about. Nor do I understand how forgetting to do something makes you able to do something, and somehow that relates to a hot stove?

Can you explain what the “hot stove” example is? Maybe that is what I’m missing.

Are you using the EA version or the standard?

Ya know a lot of ppl think pharmacists are just about putting pills in a bottle… but in all honesty in the role that I work clinically in a trauma center, I would say what sets a good pharmacist from a mediocre one is being able to catch everyone’s mistakes.

Your fellow pharmacists, techs in the pharmacy make mistakes (150 bicarb in 1/2NS?? lol) (incorrect pre packing procedures and getting kcl w an asa label)

Your docs make mistakes (2000mg q12 vanc on an esrd pt with a bmi of 45 + Zosyn 4.5 q6)

Your nurses make mistakes (y-site compatibility, missing doses, losing meds, etc)

The issue is noticing the problem and taking initiative to fix it. Unfortunately, either by ignorance, not correctly verifying, or just plain laziness can lead to sub optimal care for our patients.

It’s not easy though. I easily go through 500-1000+ orders a day, while calling doc/nurses, double checking techs and other pharmacists work. It can be stressful, and it’s easy to put blinders on and just keep hitting approve, but the pharmacists who look at that 4th 40meq kcl bag of the day for 1 patient without a lab drawn in 18 hours and calls the provider to see if maybe they want to draw a lab before the next admin. Those are the pharmacists doing a good job. This can go for the retail folks too who have to put up with way more shit than I.

Not worried in the least, house is < 10 yo and don’t plan on moving anytime soon. I also think my houses “value” is over inflated anyways.

Now if I bought in the last 3 years? Yea I might be sweating a little bit about being under water, depending on price and location.

Nice! I had it on my list, but hadn’t seen salo yet, thanks for the reminder!

A Serbian film… That ending I just cant… It is the only movie I actively tell people to avoid. My wife and I like to watch the most mind-fuck movies imaginable, but that one took it a step too far. We literally just stared at the screen for like 5 min after it was over.

So unless you live in an area with fiber, asymmetrical speeds are pretty typical… I’m not sure if it is because it’s all coax so there are infrastructure limitations? But it’s actually gotten faster because 6 months ago my upload was only 30 mbit/s.

Once fiber is in my area I’ll switch to that, but symmetrical will add more cost…but of course it will lol

Since the day before the Reddit strike… so mid June?

pay $180/month for 1gbit down/100mbit up and it is unlimited… It would be $130 for 1.75TB, but I wanted unlimited and that is an extra $50/month

Well how specific is enough to say we do or don’t know how a drug works?

In particular we do know that ASA and other NSAIDS work by inhibiting the activity of the enzyme called cyclooxygenase which leads to the formation of prostaglandins that cause inflammation, swelling, pain and fever. It blocks both COX 1 and 2, though only COX 2 is responsible inflammation. Furthermore, The antithrombotic action of aspirin is due to inhibition of platelet function by acetylation of the platelet cyclooxygenase at the functionally important amino acid serine529.

Now contrast ASA with Acetaminophen …

We know that Acetaminophen also inhibits COX, but only in the CNS and not peripherally. Also, it is only thought that it potentially blocks pain signals via the serotonergic pain pathway.

I would say we know a hell of a lot about aspirin … Acetaminophen not so much on the MOA side of things, however it has been studied so much that we know the safety/toxicity profile like the back of our hands. Either way probably not the best 2 examples to use for your argument.

God Dammit! Now Im getting SponsorBlock ads in lemmy! When will it end!

If you are using steam, you can just copy all the files from your device to hers. Then let steam validate the files and you are off to the races. My spouse and I do this all the time to save of bandwidth and time.

How do you tell you parents goodbye when the next massacre hits though?

SteamDeck Settings:

• use Github Pineapple EA Release builds
• use Update 1.1.2 + SteamsOS 3.5 if possible (make sure to delete shader cache if updating)
• Mods to use:

1. 60fpsBlackscreenfix
2. DynamixFPS++30_totk
3. Graphics - Disable LOD Quality Reduction
4. Graphics - Shadows - 512x - performance boost

• Yuzu settings under totk properties

1. CPU - Unsafe (leave all boxes checked)
2. Graphics -

• api: vulkan
• Use Disk pipline, Use asynch GPU, and Accelerate ASTC all enabled
• Window Adapting = Bilinear
• AA method = none

3. Adv Graphics

• Accuracy = normal

• Only items enabled on mine = Reactive flushing, use asynch shader block, and use vulkan pipeline cache