Why are you completely ignoring the second paper I linked, which doesn’t suffer from any of the limitations you mentioned?
The meme says no trial was successful. Any trial with any small difference is a successful trial.
Why are you completely ignoring the second paper I linked, which doesn’t suffer from any of the limitations you mentioned?
The meme says no trial was successful. Any trial with any small difference is a successful trial.
I’m not saying the study is good, just that the meme isn’t true.
Also, you can level almost every single one of those criticisms against many studies for SSRIs and they’d hit just as hard. The exception being sample size.
Not true:
https://www.sciencedirect.com/science/article/pii/S0165032714003620
https://www.cghjournal.org/article/S1542-3565(06)00800-7/fulltext
I found more, too.
Edit: I have no skin in this game. I don’t take turmeric and won’t ever because of the risk of lead. I’m just pointing out that the meme is inaccurate. The person who replied to me pointed out some flaws in the first study (not the second), but none of the flaws mentioned makes the meme accurate. Even the shitty first study I linked found a significant condition difference in its primary endpoint at 8 weeks. Yeah, it’s got flaws (which the second doesn’t), but a successful trial with heavy limitations and conflicts of interest is nonetheless a successful trial, making this meme inaccurate. The second study I linked is stronger.
Also, the limitations in the first trial are standard for many clinical trials. For example:
https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12201
https://www.sciencedirect.com/science/article/pii/S0924977X14001266
I could list 100 more with the same limitations of the first study I linked above. High dropout, small sample sizes, funding by an industry with a conflict of interest etc. are standard for clinical trial studies.
That’s not actually the abstract; it’s a piece from the discussion that someone pasted nicely with the first page in order to name and shame the authors. I looked at it in depth when I saw this circulate a little while ago.
Ah, I would consider that fluff, which is okay in my book. I don’t use it for writing, personally, but what I tell my students is that if it’d be fine for a friend to do the thing and not get coauthorship, it’s fine to use AI for that (provided you acknowledge it, as you would a friend who provides some helpful comments on a draft). Proofing and suggesting minor stylistic things fall under that umbrella IMO.
I’m in science. It isn’t difficult to get an English speaking coauthor. Going to an LLM is easier and faster, sure, but if someone can’t understand the output then they have no idea if their text is being translated correctly.
It can’t write much of substance. The only people using it in science for anything more than fluff are people who don’t speak English well or who have no business writing papers. I sympathize with the former, but I don’t understand why those folks wouldn’t just either publish in a language they speak or get an English-speaking coauthor to help write in English. I wouldn’t ever use it to write an article. Even editing, it tends to butcher scientific nuance.
It is good at writing fluff though, which is helpful for things like letters of recommendation for undergraduates.
To a degree. The large subreddits, like AskReddit, get far fewer upvotes on the top posts of the week than they used to get. I think there’s a good chunk of folks who left for a replacement, then left their replacement without going back to Reddit.
I go out of my way not to do so. Whenever I search for some specific items and see “Sponsored,” I’ll scroll down until I get the same listing without the ad link.
I’m so in the minority here, but I have a different perspective.
I worked at a grocery store for years, with about a third of my job being cart duty. I loved it when people left their carts outside of the corrals, for a few reasons.
First, if a lot of people did so, I would point it out to whoever was the manager on at the time before I went outside. My manager knew that I would take longer before coming back in, and that would give me more time to stroll/relax/enjoy the outdoors before coming back in to customer craziness. Having those extra minutes because my manager didn’t know how long I should take was nice.
Second, sometimes I had to walk way the hell out to the edge of the parking lot, which was really nice for a long walk away from customer craziness. Such walks were very nice when the weather was nice.
Third, it was job security. Working during the recession made my managers want to let as many people go as they could, but customers who made it so even the most efficient cart duty workers took a while to clear the lot effectively kept more of us employeed than management would have employed otherwise.
For those reasons, whenever the weather is nice, I try to leave my cart in a weird spot that is anchored by something. I realize that many other cart duty folks probably dislike me for it, but I know I appreciated it when others did this. So I do it for the folks like me.
I know all of the arguments against it and I’m not trying to debate here. Just sharing a different perspective; sometimes, leaving your cart in a terrible spot can be nice for some of the workers.
You are our last hope!
Well, the WHO wants information because the pneumonia that children are getting there isn’t the result of COVID and the usual other culprits. It’s a bad idea to stop travel and this is definitely just politics, but I don’t think it’s fair to say we have no evidence of a new illness. WHO thinks something is weird.
They’re Texan. I think that kind of mentality is required to live in the armpit of America.
There are still people who have terrible American accents in media. Lucifer’s twin, for example, was so ridiculously bad. The only person without an American accent who I’ve ever seen pull one off in media was Hugh Laurie in later seasons of House. I still find most attempts amusing, even with coaching.
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The Nebuchadnezzar was commissioned in 2069 in The Matrix series.
I paid for Kagi and have been super happy with it. If you don’t mind paying, I highly recommend it. Not having ads or manipulated results is worth it for me.
In the longest ultramarathon, which is 3,100 miles, men have beaten women by days every single year: https://en.m.wikipedia.org/wiki/Self-Transcendence_3100_Mile_Race
Most professors at the caliber of his institution don’t teach undergraduates, or at least don’t do so very frequently. If his workload is like most professors, his primary job is research, with mentoring PhD students and service to the department/college/field taking up the remainder of his time. Instructors and teaching professors are hired to teach undergraduate courses at major research universities. His Google Scholar shows he has still been publishing, so this was probably political:
Sorry, but this makes clear that you aren’t in science. You should avoid trying to shit on studies if you don’t know how to interpret them. Both of the things you mentioned actually support the existence of a true effect.
First, if the treatment has an effect, you would expect a greater rate of relapse after the treatment is removed, provided that it treats a more final pathway rather than the cause: People in the placebo group have already been relapsing at the typical rate, and people receiving treatment–whose disease has been ramping up behind the dam of a medication preventing it from showing–are then expected to relapse at a higher rate after treatment is removed. The second sixth-month period was after cessation of the curcumin or place; it was a follow-up for treatment-as-usual.
Second, people drop out of a study nonrandomly for two main reasons: side effects and perceived lack of treatment efficacy. The placebo doesn’t have side effects, so when you have a greater rate of dropout in your placebo group, that implies the perceived treatment efficacy was lower. In other words, the worst placebo participants are likely the extra dropouts in that group, and including them would not only provide more degrees of freedom, it would theoretically strengthen the effect.
This is basic clinical trials research knowledge.
Again, I have no skin in the game here. I don’t take curcumin, nor would I ever. I do care about accurate depictions of research. I’m a STEM professor at an R1 with three active federal grants funding my research. The meme is inaccurate.