Chezmoi has an amazing templating feature to address different files on different machines. It’s worth the time to set up.

Try out Copyq

Arch is great. You’ve kinda dipped your toes in it with Manjaro already. I recently moved to EndeavourOS with BTRFS for my gaming computer and couldn’t be happier. I could have done stock Arch but I honestly didn’t care enough to. EndeavourOS has great sane defaults and no bloat. And you can pick almost any DE during the install. Spin up a VM and give it a try if you can.

I can’t speak to MATLAB though. But all the others you mentioned I also run.

The only issue I have right now is the half screen flickering with GNOME and NVIDIA drivers. But I just ignore it.